Decreasing Seroprevalence of Measles Antibodies after Vaccination – Possible Gap in Measles Protection in Adults in the Czech Republic

Autor: Libuse Smetanova, Petr Dite, Jan Smetana, Irena Hanovcova, Šošovičková R, Roman Chlibek, Petr Gál
Jazyk: angličtina
Rok vydání: 2017
Předmět:
RNA viruses
Male
Pediatrics
Viral Diseases
Vaccination schedule
Physiology
lcsh:Medicine
Pathology and Laboratory Medicine
Biochemistry
Geographical locations
Disease Outbreaks
Cohort Studies
0302 clinical medicine
Seroepidemiologic Studies
Immune Physiology
Medicine and Health Sciences
Medicine
Public and Occupational Health
030212 general & internal medicine
Enzyme-Linked Immunoassays
lcsh:Science
Czech Republic
Aged
80 and over
Vaccines
Multidisciplinary
Immune System Proteins
biology
Middle Aged
Vaccination and Immunization
Vaccination
Europe
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Female
Pathogens
Cohort study
Research Article
Adult
medicine.medical_specialty
Adolescent
030231 tropical medicine
Immunology
Measles Vaccine
Measles Virus
Research and Analysis Methods
Measles
Microbiology
Mass Vaccination
Antibodies
Measles virus
03 medical and health sciences
Seroprevalence
Humans
Immunoassays
Microbial Pathogens
Aged
business.industry
Immunization Programs
lcsh:R
Organisms
Biology and Life Sciences
Proteins
biology.organism_classification
medicine.disease
Immunization
Age Groups
Immunoglobulin G
People and Places
Paramyxoviruses
Immunologic Techniques
lcsh:Q
Population Groupings
Measles vaccine
Preventive Medicine
business
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170257 (2017)
ISSN: 1932-6203
Popis: Aims In recent years, Europe has recorded an increase in the number of measles outbreaks despite the implementation of vaccination into the National Immunization Programs. The Czech Republic introduced vaccination against measles into National Immunization Program in 1969. The aim of this study was to determine seroprevalence of IgG antibodies against measles in adults. Methods Our study was designed as a prospective, multicenter cohort study. Samples of blood were taken from adults aged 18 years and over. Specific IgG antibodies were determined by ELISA method. Results A number of 1911 sera samples were obtained. The total seropositivity reached 83.3%, 14.3% of the results were negative and 2.4% were borderline. When comparing the individual age groups, the highest antibody seropositivity (> 96%) was detected in persons aged 50 years and over who were naturally infected in pre-vaccine era. The lowest seropositivity was recorded in the age groups 30–39 years (61.5%), 40–49 years (77.5%) and 18–29 years (81.1%). Conclusions A long term high rate of seropositivity persists after natural measles infection. By contrast, it decreases over time after vaccination. Similarly, the concentrations of antibodies in persons with measles history persist for a longer time at a higher level than in vaccinated persons. Our results indicate possible gap in measles protection in adults born after implementation of vaccination into the National Immunization Programs. There are two probable reasons, decrease of measles antibody seropositivity in time after vaccination in setting of limited natural booster and one-dose vaccination schedule used in the first years after implementation.
Databáze: OpenAIRE
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