Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature
| Autor: | Umit Baylan, Amber Korn, Hans W M Niessen, Paul A J Krijnen, Casper G. Schalkwijk, S. Simsek |
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| Přispěvatelé: | Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Pathology, ACS - Heart failure & arrhythmias, Internal medicine, ACS - Atherosclerosis & ischemic syndromes |
| Rok vydání: | 2021 |
| Předmět: |
Male
INCREASED ACCUMULATION medicine.medical_specialty Inflammation Autopsy Proinflammatory cytokine Ne carboxymethyl lysine SMALL VESSEL DISEASE INFLAMMATION Internal medicine medicine Humans Diseases of the circulatory (Cardiovascular) system Myocardial infarction OXIDATIVE STRESS Neuroinflammation Aged NADPH oxidase BLOOD-FLOW biology business.industry Lysine DEMENTIA biomarkers Aortic and Vascular Disease Cerebral Arteries Middle Aged COGNITIVE FUNCTION medicine.disease Immunohistochemistry DIABETIC-PATIENTS myocardial infarction GLYCOXIDATION PRODUCT N-EPSILON-(CARBOXYMETHYL)LYSINE RC666-701 Microvessels NADPH Oxidase 2 Neuroinflammatory Diseases Cardiology biology.protein HEART-FAILURE Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Open Heart, 8(2):e001842. BMJ Publishing Group Korn, A, Baylan, U, Simsek, S, Schalkwijk, C G, Niessen, H W M & Krijnen, P A J 2021, ' Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature ', Open Heart, vol. 8, no. 2, 001842 . https://doi.org/10.1136/openhrt-2021-001842, https://doi.org/10.1136/openhrt-2021-001842 Open Heart, Vol 8, Iss 2 (2021) Open Heart, 8(2):001842. BMJ Publishing Group Open Heart |
| ISSN: | 2053-3624 |
| Popis: | BackgroundMyocardial infarction (MI) is associated with mental health disorders, in which neuroinflammation and cerebral microvascular dysfunction may play a role. Previously, we have shown that the proinflammatory factors Nε-(carboxymethyl)lysine (CML) and NADPH oxidase 2 (NOX2) are increased in the human infarcted heart microvasculature. The aim of this study was to analyse the presence of CML and NOX2 in the cerebral microvasculature of patients with MI.MethodsBrain tissue was obtained at autopsy from 24 patients with MI and nine control patients. According to their infarct age, patients with MI were divided into three groups: 3–6 hours old (phase I), 6 hours–5 days old (phase II) and 5–14 days old (phase III). CML and NOX2 in the microvasculature were studied through immunohistochemical analysis.ResultsWe observed a 2.5-fold increase in cerebral microvascular CML in patients with phase II and phase III MI (phase II: 21.39±7.91, p=0.004; phase III: 24.21±10.37, p=0.0007) compared with non-MI controls (8.55±2.98). NOX2 was increased in microvessels in patients with phase II MI (p=0.002) and phase III MI (p=0.04) compared with controls. No correlation was found between CML and NOX2 (r=0.58, p=0.13).ConclusionsMI coincides with an increased presence of CML and NOX2 in the brain microvasculature. These data point to proinflammatory alterations in the brain microvasculature that may underlie MI-associated mental health disorders. |
| Databáze: | OpenAIRE |
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