Model Complexes Elucidate the Role of the Proximal Hydrogen-Bonding Network in Cytochrome P450s
| Autor: | Andrew P. Hunt, Matthew R. Dent, Nicolai Lehnert, Michael W. Milbauer, Subhra Samanta, Judith N. Burstyn |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Cytochrome biology 010405 organic chemistry Chemistry Stereochemistry Hydrogen bond Hydrogen Bonding 010402 general chemistry Ferric Compounds 01 natural sciences 0104 chemical sciences Inorganic Chemistry Heme B chemistry.chemical_compound Enzyme Cytochrome P-450 Enzyme System Models Chemical biology.protein Reactivity (chemistry) Sulfhydryl Compounds Physical and Theoretical Chemistry Density Functional Theory |
| Zdroj: | Inorganic Chemistry. 59:8034-8043 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/acs.inorgchem.0c00245 |
| Popis: | Cytochrome (Cyt) P450s are an important class of enzymes with numerous functions in nature. The unique reactivity of these enzymes relates to their heme b active sites with an axially bound, deprot... |
| Databáze: | OpenAIRE |
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