The Art and Practice of Systems Biology in Medicine: Mapping Patterns of Relationships
| Autor: | Stephen A. Martin, Peter Juhasz, Robert N. McBurney, Aram Adourian, Thomas N. Plasterer, Elwin Verheij, J. van der Greef |
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| Přispěvatelé: | TNO Kwaliteit van Leven |
| Rok vydání: | 2007 |
| Předmět: |
Proteomics
Serum correlation analysis Systems biology review Nanotechnology Biology Biochemistry experimental study statistical analysis Metabolomics Animals Humans Systems thinking reproducibility Analytical research Modalities business.industry Systems Biology Translational medicine Correlation networks medical information dynamics gene mapping General Chemistry Data science clinical practice priority journal Drug development protein analysis System thinking Drug Design Systems science Medicine Biological Markers Integrative medicine Personalized medicine business Biomarkers biotechnology |
| Zdroj: | Journal of Proteome Research, 4, 6, 1540-1559 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/pr0606530 |
| Popis: | Systems biology has developed in recent years from a technology-driven enterprise to a new strategic tool in Life Sciences, particularly for innovative drug discovery and drug development. Combining the ultimate in systems phenotyping with in-depth investigations of biomolecular mechanisms will enable a revolution in our understanding of disease pathology and will advance translational medicine, combination therapies, integrative medicine, and personalized medicine. A prerequisite for deriving the benefits of such a systems approach is a reliable and well-validated bioanalytical platform across complementary measurement modalities, especially transcriptomics, proteomics, and metabolomics, that operates in concert with a megavariate integrative biostatistical/bioinformatics platform. The applicable bioanalytical methodologies must undergo an intense development trajectory to reach an optimal level of reliable performance and quantitative reproducibility in daily practice. Moreover, to generate such enabling systems information, it is essential to design experiments based on an understanding of the complexity and statistical characteristics of the large data sets created. Novel insights into biology and system science can be obtained by evaluating the molecular connectivity within a system through correlation networks, by monitoring the dynamics of a system, or by measuring the system responses to perturbations such as drug administration or challenge tests. In addition, cross-compartment communication and control/feed-back mechanisms can be studied via correlation network analyses. All these data analyses depend critically upon the generation of high-quality bioanalytical platform data sets. The emphasis of this paper is on the characteristics of a bioanalytical platform that we have developed to generate such data sets. The broad applicability of Systems Biology in pharmaceutical research and development is discussed with examples in disease biomarker research, in pharmacology using system response monitoring, and in cross-compartment system toxicology assessment. © 2007 American Chemical Society. |
| Databáze: | OpenAIRE |
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