Combination 6-mercaptopurine-adriamycin in refractory adult acute leukemia
| Autor: | Robert A. Minow, John H. Casey, Kenneth B. McCredie, Mario A. Luna, Gerald P. Bodey, Emil J. Freireich, Victorio Rodriguez |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male medicine.medical_specialty Vincristine Time Factors Remission Spontaneous Gastroenterology Drug Administration Schedule Myelogenous Prednisone Internal medicine Remission Induction Therapy Humans Medicine Pharmacology (medical) Pharmacology Clinical Trials as Topic Acute leukemia Leukemia Mercaptopurine business.industry medicine.disease Blood Cell Count Doxorubicin Acute Disease Drug Therapy Combination Female business medicine.drug Chronic myelogenous leukemia |
| Zdroj: | Clinical Pharmacology & Therapeutics. 18:462-466 |
| ISSN: | 0009-9236 |
| DOI: | 10.1002/cpt1975184462 |
| Popis: | Remission induction therapy with 6MP and adriamycin in combination was administered to 19 adult leukemic patients refractory to previous therapy. Eight patients also received vincristine and prednisone. Thirteen patients had acute myelogenous leukemia, 3 undifferentiated leukemia, and 3 blastic transformation of chronic myelogenous leukemia. Four patients who died of severe infection received less than 6 wk of therapy. Four patients achieved remission but in only 2 were the remissions complete. Eleven patients failed to respond. Ten of the 19 patients developed unexpected severe liver toxicity manifested by a clinical picture of cholestasis (in the majority) or ascending cholangitis (in 2 patients). In the postmortem examination of 8 patients there was cholestasis and mild to severe hepatocellular damage in all. |
| Databáze: | OpenAIRE |
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