Mitochondrial Control of Innate Immunity and Inflammation
Autor: | Hyun-Woo Suh, Eun-Kyeong Jo, Seong-Jun Kim, Hyo Sun Jin |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Immunology Inflammation Review Article Mitochondrion Biology Inflammasome 03 medical and health sciences medicine Autophagy Immunology and Allergy chemistry.chemical_classification Innate immunity Reactive oxygen species Innate immune system Cell biology Mitochondria 030104 developmental biology Infectious Diseases chemistry medicine.symptom NLRP3 inflammasome complex Intracellular medicine.drug |
Zdroj: | Immune Network |
ISSN: | 2092-6685 1598-2629 |
Popis: | Mitochondria are key organelles involved in energy production, functioning as the metabolic hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key intracellular signaling platform regulating innate immune and inflammatory responses. Several mitochondrial proteins and mitochondrial reactive oxygen species have emerged as central players orchestrating the innate immune responses to pathogens and damaging ligands. This review explores our current understanding of the roles played by mitochondria in regulation of innate immunity and inflammatory responses. Recent advances in our understanding of the relationship between autophagy, mitochondria, and inflammasome activation are also briefly discussed. A comprehensive understanding of mitochondrial role in toll-like receptor-mediated innate immune responses and NLRP3 inflammasome complex activation, will facilitate development of novel therapeutics to treat various infectious, inflammatory, and autoimmune disorders. |
Databáze: | OpenAIRE |
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