Turmeric Extract Supplementation Reduces Tau Protein Level in Repetitive Traumatic Brain Injury Model
| Autor: | Muhammad Ichwan, Aldy Safruddin Rambe, Andre Marolop Pangihutan Siahaan, Rr Suzy Indharty, Iskandar Japardi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Turmeric extract Traumatic brain injury Tau protein Total frequency lcsh:Medicine tau protein 03 medical and health sciences 0302 clinical medicine Basic Science Internal medicine medicine Elisa method biology business.industry lcsh:R General Medicine Weight drop medicine.disease Sprague dawley 030104 developmental biology Endocrinology biology.protein Once daily business repetitive traumatic brain injury Neurotrauma 030217 neurology & neurosurgery |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences; Vol 6 No 11 (2018): Nov 25 (OAMJMS); 1953-1958 Open Access Macedonian Journal of Medical Sciences, Vol 6, Iss 11 (2018) Open Access Macedonian Journal of Medical Sciences |
| ISSN: | 1857-9655 1953-1958 |
| Popis: | BACKGROUND: Repetitive traumatic brain injury (RTBI) has gained much attention in this decade, especially in contact sports athletes and military personals. This injury is correlated with early neurodegenerative changes that are marked with the increased of tau protein. Turmeric extract (TE) is a well-known anti-inflammation and antioxidant that decreases tau protein expression in neurodegenerative disease. AIM: This study aimed to prove the effect of TE on tau protein level after RTBI. METHODS: Forty Sprague Dawley mice were divided into four groups, i.e. negative sham control group, the control group, and two treatment groups. A weight drop model was used by applying a 40-gram mass that was dropped from a 1-meter height onto the vertex of the head, with a total frequency of 12 times, divided into 4 days (day 0, 1, 3, and 7; 3 traumas on each day). TE was given to all treatment groups with 500 mg/kg BW doses once daily. The first treatment group had TE for seven days along the trauma. The second treatment group had pretreatment TE extract, given from seven days before first trauma and continued along the trauma protocol days. Tau protein level was measured on brain and serum using ELISA method. RESULTS: There was a significant reduction of tau protein level in both treatment groups compared to trauma group, either in serum or brain, but we also found significant differences regarding brain tau level between the treatment and pretreatment group. CONCLUSION: This study might provide evidence of with the role of pretreatment TE in RTBI. |
| Databáze: | OpenAIRE |
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