Is early antiretroviral therapy initiation useful in HIV(+) adults without co-infections?
| Autor: | Ximena Monsalve, Verónica Chauriye |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Tuberculosis Time Factors Anti-HIV Agents AIDS-Related Opportunistic Infections lcsh:Medicine HIV Infections Disease law.invention Randomized controlled trial law Medicine Humans Adverse effect Randomized Controlled Trials as Topic lcsh:R5-920 business.industry lcsh:R General Medicine medicine.disease CD4 Lymphocyte Count Systematic review Clinical research Immunology lcsh:Medicine (General) business |
| Zdroj: | Medwave, Vol 15, Iss Suppl 3, Pp e6326-e6326 (2015) |
| ISSN: | 0717-6384 |
| Popis: | HIV infection is a worldwide epidemic. Antiretroviral therapy has dramatically changed the outcome of the disease but there is still controversy about the best time to initiate it, especially in patients with CD4 counts over 350 cells/µL. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified two systematic reviews including four pertinent randomized controlled trials overall. We concluded early initiation of antiretroviral therapy probably reduces mortality, risk of opportunistic infections and tuberculosis, but increases the risk of important adverse effects.La infección por VIH es una epidemia a nivel mundial. El uso de terapia antirretroviral ha cambiado el pronóstico de estos pacientes, sin embargo existe controversia sobre el mejor momento para iniciarla, especialmente en pacientes con recuentos de CD4 mayores o iguales a 350 células/mm3. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en 30 bases de datos, identificamos dos revisiones sistemáticas que en conjunto incluyen cuatro estudios aleatorizados. Realizamos un metanálisis y tablas de resumen de los resultados utilizando el método GRADE. Concluimos que el uso temprano de terapia antirretroviral probablemente disminuye la mortalidad, el riesgo de enfermedades oportunistas y de tuberculosis, aunque aumenta el riesgo de efectos adversos importantes. |
| Databáze: | OpenAIRE |
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