Los Alamos Hepatitis C Virus Sequence and Human Immunology Databases: An Expanding Resource for Antiviral Research
| Autor: | James Thurmond, Lee Philip Reilly, Peter T. Hraber, Karina Yusim, Robert W Leach, Carla Kuiken |
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| Rok vydání: | 2007 |
| Předmět: |
0106 biological sciences
0301 basic medicine Databases Factual T-Lymphocytes Hepatitis C virus Hepacivirus Antibodies Viral computer.software_genre medicine.disease_cause 010603 evolutionary biology 01 natural sciences Genome Antibodies Epitope Virus Epitopes 03 medical and health sciences Flaviviridae medicine Humans Phylogeny Database biology General Medicine biology.organism_classification medicine.disease Hepatitis C United States Flavivirus 030104 developmental biology Mutation Immunology Viral hepatitis computer |
| Zdroj: | Antiviral Chemistry and Chemotherapy. 18:113-123 |
| ISSN: | 2040-2066 |
| DOI: | 10.1177/095632020701800301 |
| Popis: | The hepatitis C virus (HCV) resource at Los Alamos (hcv.lanl.gov) provides access to multiple databases: one containing annotated sequences and the other a repository of immunogenic epitopes. They are derived from databases originally developed for HIV research (hiv.lanl.gov). HCV and HIV are RNA viruses with relatively compact genomes (around 10 kb) that are extraordinarily variable, both within and between hosts. This diversity requires methods to track and exclude variants from an individual infection or from epidemiologically related infections, and tools to analyse the variation. The HCV immunology database contains a curated inventory of immunogenic epitopes and information about their interaction with the host immune system, with associated retrieval and analysis tools. This interactive resource provides flexible retrieval tools for sequences, epitopes, clinical information, and metadata, as well as utilities for scientific data analysis, to investigators with internet access and a web browser. This paper describes the types of data and the services that these databases offer, the tools they provide, and their configuration and use. Examples of applications to clonal analysis for drug-resistance mutations are shown. |
| Databáze: | OpenAIRE |
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