| Autor: |
Hesham, Salem, Ebtihal, Samir, Dina Z, Mazen, Hoda, Madian, Alshimaa E, Elkhateeb, Manar, Elaraby, Manar I, Rasekh, Aliaa, Gamal |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 274:121105 |
| ISSN: |
1386-1425 |
| Popis: |
The combination of olanzapine and samidorphan has just been authorised for the treatment of schizophrenia. The current study created a very accurate, sensitive and selective spectroscopic technique based on the first derivative of synchronous fluorescence for determining olanzapine and samidorphan in their pharmaceutical prescriptions without prior separation. For the quantitative analysis of samidorphan and olanzapine, the adopted approach is focused on measuring the synchronised fluorescence intensity of the examined medicines at fixed wavelength range (Δλ) = 50 nm and the first derivative's peak magnitudes were observed at 300 and 350 nm, respectively. The effects of various factors on the synchronised fluorescence intensity of the referenced medications were researched and adjusted. Both medications' calibrating charts were shown to be linear throughout a range of concentrations of 0.1-1.1 µg mL |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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