The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins
| Autor: | RA Murphy, Philip A. Barker |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Receptors Cell Surface Tropomyosin receptor kinase B Neurotrophin-3 Receptors Nerve Growth Factor Biology Tropomyosin receptor kinase A Tropomyosin receptor kinase C Growth factor receptor Neurotrophic factors Internal medicine Proto-Oncogenes medicine Low-affinity nerve growth factor receptor Animals Humans Nerve Growth Factors Molecular Biology Antibodies Monoclonal Cell Biology General Medicine Cell biology Endocrinology nervous system biology.protein Neurotrophin |
| Zdroj: | Molecular and cellular biochemistry. 110(1) |
| ISSN: | 0300-8177 |
| Popis: | Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) are members of a family of structurally related proteins termed neurotrophins that promote the growth and survival of neurons in the central and peripheral nervous systems. Each of these proteins bind to at least two membrane receptors. One is the low affinity nerve growth factor receptor (p75), which binds each member of the neurotrophin family. The other is one of a family of tyrosine kinase receptors--trkA binds only NGF, the related trkB receptor binds BDNF and NT-3, and trkC binds NT-3 alone. This article reviews kinetic and biochemical information on p75 and its relationship to the trk gene products. |
| Databáze: | OpenAIRE |
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