Increased incidence of penile cancer and high-grade penile intraepithelial neoplasia in Denmark 1978-2008: a nationwide population-based study
| Autor: | Birgitte Baldur-Felskov, Christian Munk, Charlotte Gerd Hannibal, Susanne K. Kjaer |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Denmark Young Adult Epidemiology medicine Confidence Intervals Prevalence Penile cancer Humans Papillomaviridae Penile Neoplasms Aged Gynecology High Grade Penile Intraepithelial Neoplasia Aged 80 and over Age differences business.industry Incidence (epidemiology) Incidence Papillomavirus Infections Middle Aged medicine.disease Population based study medicine.anatomical_structure Oncology Circumcision Male Carcinoma Squamous Cell Penile Intraepithelial Neoplasia Regression Analysis business Penis Carcinoma in Situ |
| Zdroj: | Cancer causescontrol : CCC. 23(2) |
| ISSN: | 1573-7225 |
| Popis: | To assess the trends in incidence of penile cancer during 1978-2008 and high-grade penile intraepithelial neoplasia (PIN2/3) during 1998-2008 in Denmark.Using two nationwide registries, we estimated age- and period-specific incidence rates. Log-linear Poisson regression analysis was used to estimate average annual percentage change (AAPC) and 95% confidence intervals (CI).We identified 1,488 men with penile cancer and 285 men with PIN2/3. The incidence of penile cancer increased from 1.0 to 1.3 per 100,000 men-years in 1978-1979 to 2006-2008; this represented an AAPC of 0.8% (95% CI: 0.17-1.37). Squamous cell carcinoma (SCC) was the most common histological type (91.7%). The median age at diagnosis was 67 years, and the age-specific incidence rate of penile SCC increased with increasing age. The incidence rate of PIN2/3 increased significantly (0.5 to 0.9 per 100,000 men-years) in 1998-1999 to 2006-2008, and this represented an AAPC of 7.1% (95% CI: 3.30-11.05).The incidence of penile cancer increased in 1978-2008 in Denmark, and the same applied to PIN2/3 in 1998-2008. A high prevalence of human papillomavirus (HPV) and a low circumcision rate in Denmark may partly explain our results. |
| Databáze: | OpenAIRE |
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