A review of exercise pulmonary hypertension in systemic sclerosis

Autor: Richard N. Channick, Faisal Shaikh, Rajan Saggar, Zafia Anklesaria, Tasneam Shagroni, Michael J. Ryan, Eduardo Bossone, Luna Gargani, Rajeev Saggar
Přispěvatelé: Shaikh, F, Anklesaria, Z, Shagroni, T, Saggar, R, Gargani, L, Bossone, E, Ryan, M, Channick, R
Rok vydání: 2019
Předmět:
Zdroj: J Scleroderma Relat Disord
ISSN: 2397-1991
2397-1983
DOI: 10.1177/2397198319851653
Popis: In general, pulmonary vascular disease has important negative prognostic implications, regardless of the associated condition or underlying mechanism. In this regard, systemic sclerosis is of particular interest as it is the most common connective tissue disease associated with pulmonary hypertension, and a well-recognized at-risk population. In the setting of systemic sclerosis and unexplained dyspnea, the concept of using exercise to probe for underlying pulmonary vascular disease has acquired significant interest. In theory, a diagnosis of systemic sclerosis–associated exercise pulmonary hypertension may allow for earlier therapeutic intervention and a favorable alteration in the natural history of the pulmonary vascular disease. In the context of underlying systemic sclerosis, the purpose of this article is to provide a comprehensive review of the evolving definition of exercise pulmonary hypertension, the current role and methodologies for non-invasive and invasive exercise testing, and the importance of the right ventricle.
Databáze: OpenAIRE