Involvement of three intracellular messenger systems, protein kinase C, calcium ion and cyclic AMP, in the regulation of c-fos gene expression in Swiss 3T3 cells
| Autor: | Yasuo Hamamori, Terutaka Tsuda, Yasuo Fukumoto, Takayuki Yamashita, Yoshimi Takai |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
PRKCQ
medicine.medical_treatment Biophysics Biology Biochemistry Cell Line chemistry.chemical_compound Structural Biology Cyclic AMP Genetics medicine Animals Oncogene Growth substance Protein kinase C Ca2+ cAMP (Fibroblast) RNA Messenger Alprostadil Protein kinase A Molecular Biology Protein Kinase C Protein kinase C Diacylglycerol kinase Platelet-Derived Growth Factor Forskolin Growth factor Oncogenes Cell Biology Molecular biology Fibroblast Growth Factors Gene Expression Regulation chemistry Second messenger system Ionomycin Calcium |
| Zdroj: | FEBS Letters. (1):39-42 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(86)81527-7 |
| Popis: | In quiescent cultures of Swiss 3T3 cells, platelet-derived growth factor or fibroblast growth factor known to induce both protein kinase C activation and Ca2+ mobilization raised c-fos mRNA. This action of the growth factors was mimicked by the specific activators for protein kinase C, such as phorbol esters and a membrane-permeable synthetic diacylglycerol, and also by the Ca2+ ionophores, such as A23187 and ionomycin. Prostaglandin E1 known to elevate cyclic AMP also raised c-fos mRNA, and this action was mimicked by 8-bromo-cyclic AMP, dibutyryl cyclic AMP and forskolin. These results suggest that expression of the c-fos gene is regulated by three different intracellular messenger systems, protein kinase C, Ca2+ and cyclic AMP, in Swiss 3T3 cells. |
| Databáze: | OpenAIRE |
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