Determinants of insulin sensitivity in chronic heart failure
| Autor: | P J. Senden, W. L. Mosterd, J. P. M. Wielders, I.A. Huisveld, T.W. van Haeften, L.W.E. Sabelis, A. van de Wiel, M. L. Zonderland |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Ergometry Ventricular Function Left Algemeen onderzoek Body Mass Index Cohort Studies Other medical specialities Risk Factors Internal medicine Surveys and Questionnaires Medicine Outpatient clinic Humans Insulin cardiovascular diseases Geneeskunde(GENK) Exercise Aged Heart Failure Econometric and Statistical Methods: General Analysis of Variance Ejection fraction Anthropometry business.industry Geneeskunde (GENK) Smoking Age Factors Insulin sensitivity Stroke Volume Fasting Middle Aged medicine.disease General [Econometric and Statistical Methods] Endocrinology Heart failure Chronic Disease Cardiology Etiology Glucose Clamp Technique Insulin Resistance Cardiology and Cardiovascular Medicine business Body mass index Cohort study |
| Zdroj: | European Journal of Heart Failure, 5(6), 759. Oxford University Press |
| ISSN: | 1388-9842 |
| Popis: | Objective: To describe the determinants of insulin sensitivity (IS) in chronic heart failure (CHF), we created a model in which the influence of lifestyle factors and etiology of heart failure on IS were incorporated concomitantly with age, left ventricular ejection fraction (LVEF) and parameters of body composition. Design: Observational cohort study. Setting: Outpatient clinic for chronic heart failure. Patients: Fifty-seven male CHF patients [NYHA class II–III, age 61±9 years, body mass index (BMI) 26.9±3.3 kg/m2 (mean±S.D.)]. Interventions: Euglycemic hyperinsulinemic clamp, cycle ergometry, anthropometric measurements, LVEF and a physical activity questionnaire. Main outcome measures: A model explaining the variance of IS in CHF. Results: IS was 18.2±8.6 μg·kg−1·min−1·mU−1·l−1, fasting insulin level was 15.9±11.0 mU/l and fasting glucose level was 5.5±0.6 mmol/l. Peak was 19.1±4.9 ml·kg−1·min−1 and LVEF 26.2±7.1%. IS was inversely associated with fasting insulin concentration (r=−0.50, P |
| Databáze: | OpenAIRE |
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