ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs
| Autor: | Adam Solomon, Miki Hatzav, Ronen Alon, Moria Lichtenstein, Dena Leshkowitz, Ofer Regev, Adi Biram, Sara W. Feigelson, Diana Varol, Steffen Jung, Ziv Shulman, Stav Kozlovski, Caterina Curato |
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| Rok vydání: | 2018 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine Priming (immunology) Inflammation Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Immune system Antigen antigens medicine Humans lcsh:QH301-705.5 Lymph node T cell activation T-cell receptor Dendritic Cells adaptive immunity differentiation Dendritic cell Intercellular Adhesion Molecule-1 vaccination Acquired immune system Cell biology 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) inflammation Lymph Nodes medicine.symptom 030215 immunology |
| Zdroj: | Cell Reports Cell Reports, Vol 22, Iss 4, Pp 849-859 (2018) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2017.12.103 |
| Popis: | Summary Protective immune responses depend on the formation of immune synapses between T cells and antigen-presenting cells (APCs). The two main LFA-1 ligands, ICAM-1 and ICAM-2, are co-expressed on many cell types, including APCs and blood vessels. Although these molecules were suggested to be key players in immune synapses studied in vitro , their contribution to helper T cell priming in vivo is unclear. Here, we used transgenic mice and intravital imaging to examine the role of dendritic cell (DC) ICAM-1 and ICAM-2 in naive CD4 T cell priming and differentiation in skin-draining lymph nodes. Surprisingly, ICAM deficiency on endogenous CD40-stimulated lymph node DCs did not impair their ability to arrest and prime CD4 lymphocyte activation and differentiation into Th1 and Tfh effectors. Thus, functional T cell receptor (TCR)-specific helper T cell synapses with antigen-presenting DCs and subsequent proliferation and early differentiation into T effectors do not require LFA-1-mediated T cell adhesiveness to DC ICAMs. |
| Databáze: | OpenAIRE |
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