Excess of Post-Acute Sequelae of COVID-19 After the First Wave of the Pandemic

Autor: Marc Scherlinger, Cédric Lemogne, Renaud Felten, Jean Sibilia
Rok vydání: 2022
Předmět:
Zdroj: Infectious Diseases and Therapy. 11:2279-2285
ISSN: 2193-6382
2193-8229
DOI: 10.1007/s40121-022-00698-6
Popis: To compare the time distribution of initial COVID-19 among patients with self-reported post-acute sequelae of COVID-19 (PASC).We compared the distribution of the date of the reported initial COVID-19 among patients with self-reported PASC and the COVID-19 cases in France between the first wave (January 1-May 11, 2020) and the later period (May 12, 2020-June 30, 2021) using the chi-squared test. COVID-19 cases in France were assessed using previous modeling of COVID-19 burden in France for the first time period, and positive RT-PCR testing for the second time period.The study included 567 individuals with PASC (median age 44, [IQR 37-50]; 83.4% women). A total of 293 (51.7%) patients reported an initial COVID-19 infection during the first period while 272 (48%) reported it during the later period (missing data, n = 2; 0.3%). Patients with PASC were 82% more likely to report initial COVID-19 during the first pandemic wave than afterward (OR 1.82, 95% CI [1.55-2.15]; p 0.0001).The incidence of self-reported PASC wave was significantly higher when initial COVID-19 happened during the first pandemic wave than afterward, suggesting the importance of non-viral factors in PASC development.
Databáze: OpenAIRE
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