Multiple-dose efficacy comparison of the two topical carbonic anhydrase inhibitors sezolamide and MK-927
| Autor: | Erik L. Greve, Jean-Luc George, Alain M. Bron, Frans P. Gunning, Erik A. Lippa, Jean G. Royer, Coleen Clineschmidt, F. Brunner-Ferber, Agnes Buntinx, Pierre Lesure, Jacques Flament, Daniel Sirbat, Deborah L. Panebianco, Claude Bénichou |
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| Přispěvatelé: | Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon) |
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Intraocular pressure Evening medicine.drug_class Administration Topical [SDV]Life Sciences [q-bio] Ocular hypertension Glaucoma Thiophenes Placebo Double-Blind Method Medicine Humans Carbonic anhydrase inhibitor Carbonic Anhydrase Inhibitors Intraocular Pressure Morning Aged Aged 80 and over Sulfonamides Dose-Response Relationship Drug business.industry Parallel study Stereoisomerism Middle Aged medicine.disease Circadian Rhythm Ophthalmology Anesthesia Female Ocular Hypertension business Glaucoma Open-Angle |
| Zdroj: | Archives of Ophthalmology-New Series Archives of Ophthalmology-New Series-, American Medical Association, 1991, 109 (1), pp.50-53 |
| ISSN: | 0003-9950 |
| Popis: | International audience; The multiple-dose twice-daily efficacy of the topical carbonic anhydrase inhibitor MK-927, a racemic compound, was compared with that of its pharmacologically more active S-enantiomer in a four-center, double-masked, randomized, placebo-controlled, parallel study of 1.8% sezolamide hydrochloride (MK-417), 2% MK-927, and placebo, given twice daily to 48 patients with bilateral primary open angle glaucoma or ocular hypertension and morning intraocular pressure greater than 24 mm Hg in both eyes following washout of ocular hypotensive medications. Parallel 10-hour modified diurnal curves were performed before the study and on day 14, with 4-hour curves on days 1 and 4. Both compounds demonstrated significant lowering of intraocular pressure at 8 AM, 12 hours following the evening dose, and through 10 and 6 hours following the 8 AM dose for sezolamide and MK-927, respectively. Morning trough (evening) activity as measured by mean percent change in intraocular pressure from prestudy was -9.2% for sezolamide and -11.1% for MK-927 (-13.5% and -9.6%); peak effect occurred 2 hours after dose administration and was -19.4% and -19.2% for sezolamide and MK-927, respectively. From 2 hours after dose administration, sezolamide consistently demonstrated a slightly greater decrease in intraocular pressure than MK-927; however, these differences were not statistically significant. |
| Databáze: | OpenAIRE |
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