Nonlinear optical 3-dimensional method for quantifying atherosclerosis burden
| Autor: | Nerea Méndez-Barbero, Antonio M. Santos-Beneit, Juan Miguel Redondo, Vanesa Esteban, Miguel R. Campanero, Luis Jesús Jiménez-Borreguero, Susana A. Sánchez |
|---|---|
| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Ministerio de Educación, Cultura y Deporte (España), Fundació La Marató de TV3, Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (España), Fundación Pro CNIC, Ministerio de Sanidad, Servicios Sociales e Igualdad (España) |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Confocal Aorta Thoracic Severity of Illness Index Diagnosis Differential Nonlinear optical chemistry.chemical_compound Mice Imaging Three-Dimensional Plaque volume medicine Image Processing Computer-Assisted Oil Red O Animals Radiology Nuclear Medicine and imaging Coloring Agents Microscopy Confocal biology business.industry Reproducibility of Results Single excitation medicine.disease Atherosclerosis Image Enhancement Plaque Atherosclerotic Disease Models Animal Atheroma chemistry Nonlinear Dynamics biology.protein Cardiology and Cardiovascular Medicine business Elastin Ex vivo Biomedical engineering |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1942-0080 1941-9651 |
| Popis: | Changes in atherosclerosis burden provide an experimental measure of the effectiveness of therapeutic strategies. Unfortunately, none of the methods used in mice to assess atherosclerosis burden ex vivo is sufficiently accurate and fast enough to process the number of samples required in preclinical studies. We aimed to design an easy-to-implement and relatively fast method for accurate volumetric quantification of atheroma plaque burden in mice. Dr Redondo is supported by the Spanish Ministry of Economy and Competitiveness (MINECO; SAF2009-10708 and SAF2012-34296) and Fundación La Marató TV3 (264/C/2012). The Red de Investigación Cardiovascular of the Spanish Ministry of Health (Ministerio de Sanidad) supports Dr Redondo (RD12/0042/0022) and Dr Jiménez-Borreguero (RD12/0042/0056). Dr Campanero was supported by MINECO (SAF2010-15126). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Science and Innovation and the Pro-CNIC Foundation. N. Méndez-Barbero holds a Formacion del Profesorado Universitario fellowship (FPU2008-1500). |
| Databáze: | OpenAIRE |
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