A three-generation study on the association of tobacco smoking with asthma
| Autor: | Angelo Corsico, John W. Holloway, Lucia Calciano, Joachim Heinrich, Bertil Forsberg, Bénédicte Leynaert, Sandra Dorado Arenas, Jesús Martínez-Moratalla Rovira, Deborah Jarvis, Roberto Bono, Anne-Elie Carsin, Julia Dratva, Dennis Nowak, Joost Weyler, Vivi Schlünssen, Shyamali C. Dharmage, Alessandro Marcon, Cecilie Svanes, Francisco Gómez Real, Randi Jacobsen Bertelsen, Andrei Malinovschi, Pascal Demoly, Christer Janson, Lennart Bråbäck, Bryndis Benediktsdottir, Simone Accordini, José Luis Sánchez-Ramos, Rain Jõgi, Ane Johannessen, Laura Portas, Mathias Holm, Chantal Raherison, Isabelle Pin |
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| Přispěvatelé: | Medical Research Council (MRC), Commission of the European Communities, CIBER de Epidemiología y Salud Pública (CIBERESP), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Diagnostics and Public Health [Verona] (UNIVR | DDSP), University of Verona (UNIVR), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service d'allergologie et de pneumologie [Hôpital Arnaud de Villeneuve], Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Department of Medicine and Public Health, Università degli Studi di Verona, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Parents fathers' smoking during puberty Epidemiology Respiratory Medicine and Allergy [SDV]Life Sciences [q-bio] Ageing Lungs in European Cohorts (ALEC) Study RESPIRATORY-HEALTH-SURVEY OBSTRUCTIVE LUNG-DISEASE 616: Innere Medizin und Krankheiten smoking during pregnancy mothers' smoking during pregnancy Risk Factors Tabac father fathers’ smoking during puberty Medicine Meðganga Young adult Child Lungmedicin och allergi Public Environmental & Occupational Health Smoking 0104 Statistics Public Health Global Health Social Medicine and Epidemiology General Medicine Foreldrar Middle Aged grandmothers’ smoking during pregnancy Astmi Obstructive lung disease 3. Good health Europe smoking during puberty PREGNANCY 1117 Public Health And Health Services Child Preschool Prenatal Exposure Delayed Effects Cohort Multilevel Analysis Regression Analysis Asthma mothers’ smoking during pregnancy grandmothers’ smoking during pregnancy fathers’ smoking during puberty multilevel mediation model Ageing Lungs in European Cohorts (ALEC) Study Female TRANSGENERATIONAL RESPONSES Biological plausibility Reykingar Life Sciences & Biomedicine Adult EXPRESSION medicine.medical_specialty Adolescent Offspring mothers’ smoking during pregnancy INHERITANCE 03 medical and health sciences Arbetsmedicin och miljömedicin Young Adult Environmental health Tobacco Tobacco Smoking MATERNAL NICOTINE EXPOSURE Humans COHORT multilevel mediation model tobacco smoking Preschool Asma Asthma Aged Pregnancy ageing lungs in European cohorts (ALEC) stud Science & Technology business.industry Infant Newborn Australia Infant CHILDHOOD ASTHMA Occupational Health and Environmental Health medicine.disease Newborn Health Surveys Grandparents grandmothers' smoking during pregnancy mothers parent Folkhälsovetenskap global hälsa socialmedicin och epidemiologi 030104 developmental biology Óbeinar reykingar Human medicine Smoking in pregnancy business FOLLOW-UP |
| Zdroj: | International Journal of Epidemiology International Journal of Epidemiology, Oxford University Press (OUP), 2018, 47 (4), pp.1106--1117. ⟨10.1093/ije/dyy031⟩ Dipòsit Digital de la UB Universidad de Barcelona Ageing Lungs in European Cohorts (ALEC) Study (Vivi Schlünssen; member) 2018, ' A three-generation study on the association of tobacco smoking with asthma ', International Journal of Epidemiology, vol. 47, no. 4, pp. 1106-1117 . https://doi.org/10.1093/ije/dyy031 International journal of epidemiology Recercat. Dipósit de la Recerca de Catalunya instname |
| ISSN: | 0300-5771 1464-3685 |
| DOI: | 10.1093/ije/dyy031⟩ |
| Popis: | Publisher's version (útgefin grein) Background Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55). Conclusions Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study [www.alecstudy.org], which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212. The coordination of the European Community Respiratory Health Survey (ECRHS) was supported by the European Commission (phases 1 and 2) and the Medical Research Council (phase 3). Local funding agencies for the ECRHS are reported in the Supplementary Appendix, available as Supplementary data at IJE online. Conflict of interest: J.W.H. reports grants from the European Union’s Horizon 2020 programme (633212), the Medical Research Council UK (MC_PC_15078) and the National Institutes of Health USA (R01 AI091905, R01 AI121226) during the conduct of the study. R.J. reports grants from the Estonian Research Council (personal grant No. 562) during the conduct of the study, grants/grants pending from the Estonian Research Council (personal research grant No. 562), personal fees for consulting and lecturing from GlaxoSmithKline, Boehringer and Novartis and travel/accommodation/meeting expenses paid by GlaxoSmithKline and Boehringer, outside the submitted work. C.R. reports personal fees for consulting and lecturing from ALK, Astra Zeneca, GSK, Boheringer and Novartis, outside the submitted work. A.G.C. reports grants from Chiesi Farmaceutici and GlaxoSmithKline Italy, during the conduct of the study. P.D. reports personal fees for consulting and lecturing from ALK and Stallergenes Greer and personal fees for consulting from Circassia, Chiesi Farmaceutici, ThermofisherScientific and Menarini, outside the submitted work. D.J. reports grants from the Medical Research Council and the European Union’s Horizon 2020 programme, during the conduct of the study. All other authors declare no competing interests. |
| Databáze: | OpenAIRE |
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