Atrial natriuretic peptide differentially modulates T- and L-type calcium channels
| Autor: | W. B. Bollag, R. T. McCarthy, C. M. Isales, H. Rasmussen, P. Q. Barrett |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Aldosterone Voltage-dependent calcium channel Physiology Calcium channel Osmolar Concentration T-type calcium channel chemistry.chemical_element Biology Calcium Angiotensin II Electrophysiology chemistry.chemical_compound Endocrinology Atrial natriuretic peptide chemistry Internal medicine Adrenal Glands medicine L-type calcium channel Calcium Channels hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor Cells Cultured |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0002-9513 |
| Popis: | Atrial natriuretic peptide (ANP) inhibits the secretion of aldosterone stimulated by any of these major physiological agonists: angiotensin II, adrenocorticotropic hormone, or K+. The stimulatory actions of each of these agonists depend on calcium influx through voltage-dependent calcium channels. Because two types of calcium channels have been previously described in bovine glomerulosa cells (T- and L-type), the patch-clamp technique was used to evaluate the effect of ANP on each voltage-dependent calcium channel type. ANP was found to differentially modulate these two channel types, stimulating L-current while inhibiting T-current. Inhibition of T-current resulted from a shift in the voltage dependence of inactivation to more negative potentials within the physiological range. These results indicate that the ANP-induced inhibition of aldosterone secretion may be partially mediated via a reduction of the calcium current through T-type channels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|