Association between the catechol-o-methyltransferase val158met polymorphism with susceptibility and severity of carpal tunnel syndrome
| Autor: | S Ozemri Sag, E Erkol İnal, Tahsin Yakut, Gorukmez O, Pınar Eroğlu |
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| Rok vydání: | 2015 |
| Předmět: |
catechol-o-methyltransferase (comt) gene
medicine.medical_specialty Future studies Visual analogue scale Population boston questionnaire QH426-470 Gastroenterology 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Internal medicine Genotype Genetics medicine pain Carpal tunnel syndrome education Genetics (clinical) education.field_of_study Catechol-O-methyl transferase business.industry val158met (rs4680) polymorphism medicine.disease nervous system diseases Surgery carpal tunnel syndrome (cts) business 030217 neurology & neurosurgery rs4680 |
| Zdroj: | Balkan Journal of Medical Genetics, Vol 18, Iss 2, Pp 43-48 (2015) |
| ISSN: | 1311-0160 |
| DOI: | 10.1515/bjmg-2015-0085 |
| Popis: | Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. In this study, we aimed to clarify the relationships between the catechol-O-methyltransferase (COMT) gene Val158Met (rs4680) polymorphism and development, functional and clinical status of CTS. Ninety-five women with electro diagnostically confirmed CTS and 95 healthy controls were enrolled in the study. The functional and clinical status of the patients was measured by the Turkish version of the Boston Questionnaire and intensity of pain related to the past 2 weeks was evaluated on a visual analog scale (VAS). The Val158Met polymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), method. We divided patients according to the genotypes of the Val158Met polymorphism as Val/Val, Val/Met and Met/Met. There were not any significant differences in terms of Val158Met polymorphisms between patients and healthy controls (p >0.05). We also did not find any relationships between the Val158Met polymorphism and CTS (p >0.05). In conclusion, although we did not find any relationships between CTS and the Val158Met polymorphism, we could not generalize this result to the general population. Future studies are warranted to conclude precise associations. |
| Databáze: | OpenAIRE |
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