Evaluation of a new hepatitis B triple-antigen vaccine in inadequate responders to current vaccines
| Autor: | Arie J. Zuckerman, Ian Symington, Michael D. Young, Anthony Williams, Brian Dickson, Jane N. Zuckerman, Wei Du |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male HBsAg Hepatitis B vaccine Double-Blind Method Antigen medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Protein Precursors Aged Hepatitis B Surface Antigens Hepatology business.industry Antibody titer Middle Aged Hepatitis B medicine.disease Virology Titer Immunization Immunology Female Viral disease business |
| Zdroj: | Hepatology. 34:798-802 |
| ISSN: | 0270-9139 |
| Popis: | In this double-blind, randomized, controlled study, healthcare professionals with a history of inadequate response to currently available single-antigen hepatitis B vaccines confirmed by measuring hepatitis B surface antibody titer before entry to the study were revaccinated with a 20-microg dose either of a novel triple-antigen (S, pre-S1, and pre-S2) recombinant vaccine or of a present single-antigen (S only) vaccine. Hepatitis B surface antibody titers were measured 8 weeks' post revaccination. A total of 925 individuals were randomized and vaccinated, of whom 915 (98.9%) completed the study and were included in the efficacy analysis. A single dose of the new triple-antigen hepatitis B vaccine (Hepacare) produced a successful response in over three quarters of these subjects who had not mounted an adequate response to current vaccines. The antibody response was statistically significantly superior (P =.002) to that after a single dose of current vaccines. An evaluation of the overall response showed that only the triple-antigen vaccine was able to raise the average antibody response (geometric mean titer [GMT]) to over 100 IU/L. The superior effect of the new vaccine was most pronounced in subjects who were previously complete nonresponders to currently available hepatitis B vaccines. Both vaccines were well tolerated and had similar safety profiles. This study demonstrated that in healthcare workers who had responded inadequately to at least a full course of immunization (median, 5 doses), a single 20-microg dose of a new triple-antigen vaccine induced protective antibody level in more vaccinees (P =.002) and increased the average antibody titer (GMT) in those protected successfully to a greater degree (P |
| Databáze: | OpenAIRE |
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