Discontinuation of Antiretroviral Therapy Commenced Early during the Course of Human Immunodeficiency Virus Type 1 Infection, with or without Adjunctive Vaccination
| Autor: | Linqi Zhang, Viviana Simon, Bharat Ramratnam, Tian He, Xia Jin, John M. Murray, Murugappan Ramanathan, Jeroen Vanderhoeven, Martin Markowitz, Chris Chung, Geoffrey R. Deschenes, Michael Louie, Arlene Hurley, David D. Ho, Shady Barsoum, Alan S. Perelson |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty HIV Infections Viremia Virus Adjuvants Immunologic Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Internal medicine Immunopathology medicine Humans Immunology and Allergy Longitudinal Studies Sida AIDS Vaccines biology business.industry Vaccination medicine.disease biology.organism_classification CD4 Lymphocyte Count Discontinuation Infectious Diseases Immunology HIV-1 RNA Viral Female Viral disease business |
| Zdroj: | The Journal of Infectious Diseases. 186:634-643 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Sixteen subjects were treated with highly active antiretroviral therapy within 120 days of the onset of symptoms of newly acquired human immunodeficiency virus type 1 (HIV-1) infection. Eleven of the 16 participated in an adjunctive therapeutic vaccine trial. After a mean of 3.2 years of treatment, they elected to discontinue therapy. Virus rebound occurred in all subjects and was followed by a spontaneous, transient although significant reduction in log plasma HIV-1 RNA level, ranging from 0.3 to 3.1 log(10) copies/mL. Despite evidence of the induction of HIV-1-specific cell-mediated immune responses, plasma viremia was not persistently suppressed to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|