| Autor: |
James R. Downing, Jianmin Wang, Walter H. Lang, Fred Krafcik, Michael Rusch, Kristy Boggs, Matthew Parker, Michael N. Edmonson, Nilsa C. Ramirez, Lei Wei, Steve Skapek, Li Ding, Anang A. Shelat, Justina McEvoy, Sara M. Federico, Elaine R. Mardis, Sheila A. Shurtleff, Jinghui Zhang, Heather L. Mulder, John A. Sandoval, Lyudmila Tsurkan, Andrew M. Davidoff, Viktor Tolleman, Charles Lu, Gang Wu, Chunxu Qu, Sheri L. Spunt, Cori Bradley, Panduka Nagahawatte, Elizabeth Stewart, Douglas S. Hawkins, Marcus B. Valentine, Richard K. Wilson, Philip M. Potter, Donald Yergeau, Xiang Chen, David Finkelstein, Monika Wierdl, Erin Hedlund, John Easton, Armita Bahrami, Virginia Valentine, Mark E. Hatley, Alberto S. Pappo, Christopher L. Morton, Michael A. Dyer |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Cancer Cell. 24:710-724 |
| ISSN: |
1535-6108 |
| Popis: |
SummaryRhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and copy number variations than alveolar tumors. Mutations in the RAS/NF1 pathway are significantly associated with intermediate- and high-risk embryonal rhabdomyosarcomas (ERMS). In contrast, alveolar rhabdomyosarcomas (ARMS) have fewer genetic lesions overall and no known recurrently mutated cancer consensus genes. To identify therapeutics for ERMS, we developed and characterized orthotopic xenografts of tumors that were sequenced in our study. High-throughput screening of primary cultures derived from those xenografts identified oxidative stress as a pathway of therapeutic relevance for ERMS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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