Microwave-Promoted Tin-Free Iminyl Radical Cyclization with TEMPO Trapping: A Practical Synthesis of 2-Acylpyrroles

Autor:	Yu Cai, Steven L. Castle, Ankur Jalan, Aaron R. Kubosumi
Rok vydání:	2015
Předmět:	Chemistry Organic Chemistry chemistry.chemical_element Single step Trapping Oxime ether Photochemistry Biochemistry Radical cyclization Adduct Reagent Physical and Theoretical Chemistry Tin Microwave
Zdroj:	Organic Letters. 17:488-491
ISSN:	1523-7052 1523-7060
Popis:	Microwave-promoted iminyl radical cyclizations can be terminated by trapping with TEMPO, affording functionalized adducts. The use of alkynes as radical acceptors delivers a range of 2-acylpyrroles in good yields. Toxic and hazardous reagents, which are frequently employed in radical reactions, are not required. The O-phenyl oxime ether substrates are constructed in a single step from readily available ketones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cef27af49709457a28eba89fdd42e0 https://doi.org/10.1021/ol5035047 Zobrazit plný text záznamu