Association Between Cardiac High-Energy Phosphate Metabolism and Whole Body Metabolism in Healthy Female Adults
| Autor: | Dejana Popovic, Kieren G. Hollingsworth, Guy A. MacGowan, Prisca G Wibowo, Lazar Velicki, Nduka C Okwose, Djordje G. Jakovljevic, Sarah J. Charman |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose 0301 basic medicine High-energy phosphate Aging medicine.medical_specialty Phosphocreatine Physiology chemistry.chemical_element 030204 cardiovascular system & hematology Oxygen Body Mass Index 03 medical and health sciences Adenosine Triphosphate Oxygen Consumption 0302 clinical medicine Internal medicine medicine Humans Exercise Adiposity Aged 2. Zero hunger business.industry Myocardium Articles General Medicine Metabolism Middle Aged medicine.disease 030104 developmental biology Endocrinology chemistry Heart failure Basal metabolic rate Metabolic rate Female business Whole body Body mass index |
| Zdroj: | Europe PubMed Central Physiol Res |
| ISSN: | 1802-9973 0862-8408 |
| Popis: | Decline in cardiac high-energy phosphate metabolism [phosphocreatine-to-ATP (PCr/ATP) ratio] and whole body metabolism increase the risk of heart failure and metabolic diseases. The aim of the present study was to assess the relationship between PCr/ATP ratio and measures of body metabolic function. A total of 35 healthy women (56±14.0 years of age) underwent cardiac 31P magnetic resonance spectroscopy to assess PCr/ATP ratio – an index of cardiac high-energy phosphate metabolism. Fasting and 2-hour glucose levels were assessed using oral glucose tolerance test. Indirect calorimetry was performed to determine oxygen consumption and resting metabolic rate. There were no significant relationships between PCr/ATP ratio and resting metabolic rate (r=-0.09, p=0.62), oxygen consumption (r=-0.11, p=0.54), fasting glucose levels (r=-0.31, p=0.07), and 2-hour plasma glucose (r=-0.10, p=0.58). Adjusted analysis for covariates including age, body mass index, fat mass, and physical activity, had no significant influence on the relationship between PCr/ATP ratio and body metabolism. In conclusion, the lack of relationship between cardiac PCr/ATP ratio, glucose control and metabolic rate may suggest that overall metabolic function does not influence cardiac high-energy phosphate metabolism. |
| Databáze: | OpenAIRE |
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