Respiratory autoresuscitation following severe acute hypoxemia in anesthetized adult rats
| Autor: | Rebeka Srbu, Andrew Krause, Harold James Bell, Zachary Nowak |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine Pentobarbital Physiology Resuscitation Respiratory arrest Blood Pressure Hypoxemia Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Heart Rate Heart rate medicine Animals Hypnotics and Sedatives Anesthesia Respiratory system Hypoxia Analysis of Variance Eupnea business.industry Respiration General Neuroscience Respiratory Aspiration Recovery of Function Hypoxia (medical) Rats Disease Models Animal 030104 developmental biology Anesthetic medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Respiratory Physiology & Neurobiology. 232:43-53 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2016.06.006 |
| Popis: | In the present study we investigated the pattern and efficacy of respiratory autoresuscitation in spontaneously breathing adult male rats across three separate anesthetic backgrounds. Each animal was administered one of three injectable anesthetics to achieve a surgical plane of anesthesia: ketamine-xylazine (KET, n=10), pentobarbital (PEN, n=10), or urethane (URE, n=10). Animals were tracheostomized and equipped with a femoral artery catheter to record airflow and arterial pressures. In response to a bout of breathing anoxic air, none of the 10 URE animals were able to mount a successful autoresuscitation response. In contrast, all KET and PEN animals survived all four consecutive anoxic exposures, restoring eupneic breathing in all cases. Moreover, only 4/10 URE animals expressed gasping breaths following the onset of respiratory arrest, and these were temporally delayed (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect