Inhibitory effect of exogenous IL‐4 on orthodontic relapse in rats
| Autor: | Minting Wu, Jing Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Molar Tooth Movement Techniques medicine.medical_treatment Osteoclasts Dentistry Mandibular first molar Bone remodeling Rats Sprague-Dawley Mandibular second molar 03 medical and health sciences 0302 clinical medicine stomatognathic system Recurrence Osteoclast medicine Animals General Dentistry Saline business.industry 030206 dentistry Periodontium Buccal administration Rats medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Interleukin-4 business |
| Zdroj: | Oral Diseases. 28:469-479 |
| ISSN: | 1601-0825 1354-523X |
| Popis: | Objective Interleukin-4 is proven to regulate bone metabolism. This study aimed to assess the effect of exogenous interleukin-4 on orthodontic relapse. Materials and methods Bilateral maxillary first molars of 25 male Sprague Dawley rats were moved mesially for 3 weeks using orthodontic appliances an activating force of 50 g. After tooth movement, exogenous interleukin-4 was injected into the buccal and palatine sides of the right maxillary first molars (experimental group), and phosphate-buffered saline was injected at the same sites on the left side (negative control group). At the end of the study, the relapse distance between the mesial fissure of the first molar and the distal fissure of the second molar was measured. Three different histological stains were used to visualize the changes in the periodontium. Results After interleukin-4 injection, the relapse distance significantly reduced. Time-dependent effects played a more important role than the dose-dependent effects, and there was no correlation between these factors. Tissue staining showed that interleukin-4 reduced osteoclastogenesis and promoted osteoblastogenesis. Conclusion Exogenous interleukin-4 reduced the relapse of orthodontically treated teeth by promoting osteoblastogenesis and inhibiting osteoclastogenesis. Our findings can potentially benefit specialists in the future by improving their patients' treatment outcomes. |
| Databáze: | OpenAIRE |
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