Role of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Evaluation of Cytologically Indeterminate Thyroid Nodules
| Autor: | Yasemin Aktar, Husnu Sonmez, Gulgun Buyukdereli, Ertan Kara, Aysun Uguz |
|---|---|
| Přispěvatelé: | Çukurova Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Thyroid nodules
medicine.medical_specialty 030209 endocrinology & metabolism Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine medicine Thyroid Nodules Radiology Nuclear Medicine and imaging Fine Needle Aspiration Biopsy Thyroid cancer Pathological medicine.diagnostic_test business.industry Thyroid Indeterminate medicine.disease FDG PET/CT medicine.anatomical_structure Positron emission tomography 030220 oncology & carcinogenesis Histopathology Radiology Nuclear Medicine Nuclear medicine business |
| Zdroj: | Iranian Journal of Radiology |
| ISSN: | 2008-2711 1735-1065 |
| Popis: | Background: Thyroid nodules with indeterminate fine-needle aspiration biopsy (FNAB) results remain a diagnostic dilemma, because 70 - 85% of these nodules have been found to be benign after thyroid surgery. Objectives: The purpose of this study was to evaluate the usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative diagnosis of cytologically indeterminate nodules. Patients and Methods: Forty-six patients were included in this study. These individuals had undergone FDG PET/CTs for the preoperative evaluation of thyroid nodules with indeterminate FNAB results. The results of the preoperative PET/CT scans were compared with the postoperative pathological results and statistically analyzed. Results: Of the 46 patients included in our study, the histopathology of the surgical specimens revealed thyroid cancer in 17 individuals (37%, 17/46). The PET/CT scan showed a positive result in 27 patients. Of these, 16 patients (59.3%) were found to have thyroid carcinomas. In addition, the PET/CT scan was considered to be negative in 19 patients, 18 (94.7%) of whom had benign lesions. For the detection of malignant lesions, the values for the sensitivity and specificity, and the positive predictive and negative predictive values were 94%, 62%, 59%, and 95%, respectively. Conclusion: The FDG PET/CT showed a high sensitivity and a high negative predictive value for identifying malignancies in thyroid nodules with indeterminate FNAB results. Therefore, the FDG PET/CT may be a helpful tool in the clinical management of these nodules. When an FDG positive lesion is detected, further examination is recommended. © 2016, Tehran University of Medical Sciences and Iranian Society of Radiology. |
| Databáze: | OpenAIRE |
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