Spherical Caps in Cell Polarization
| Autor: | Hadrien Montanelli, Stanislav Y. Shvartsman, Cyrill B. Muratov, Rocky Diegmiller |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Parametric analysis Biophysical Letters Chemistry Cell Membrane Biophysics Intracellular Space Spherical cell Cell Polarity 010103 numerical & computational mathematics 01 natural sciences Models Biological Diffusion 03 medical and health sciences Multicellular organism 030104 developmental biology Membrane Cytoplasm Symmetry breaking 0101 mathematics Cell Shape Intracellular |
| Zdroj: | Biophysical journal. 115(1) |
| ISSN: | 1542-0086 |
| Popis: | Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|