| Autor: |
Jonathon J. Parker, Cammie E. Rolle, Rajat S. Shivacharan, Daniel A.N. Barbosa, Austin Feng, Yuhao Huang, Bina W. Kakusa, Tom Prieto, Richard A. Jaffe, Nolan R. Williams, Casey H. Halpern |
| Rok vydání: |
2022 |
| Předmět: |
|
| DOI: |
10.1101/2022.09.12.22279834 |
| Popis: |
There is strong evidence for the putative role of the nucleus accumbens (NAc) in appetitive motivation. A first-in-human feasibility trial of responsive deep brain stimulation (rDBS) for loss of control eating provided a rare opportunity to examine the physiologic and structural underpinnings of NAc function in a human participant with dysregulated appetition. Patient-specific probabilistic tractography was supplemented by intraoperative microelectrode recordings and stimulation testing to confirm appetitive circuit engagement. Personalized visual stimuli we used to provoke and map appetitive units within the NAc, prior to the surgical implantation of a rDBS system, which was safe, feasible, and well-tolerated. Ambulatory patient-triggered recordings provide ongoing electrophysiologic surveillance of NAc activity time-locked to eating behavior in the real-world. This technique described provides a proof-of-concept for utilizing simultaneous intracranial activity and real-time appetitive responses to guide implantation of a rDBS system to treat loss of control eating. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
