Cytotoxic meroterpenoids from the macroalga Cystoseira abies-marina
| Autor: | Anake Kijjoa, Vera L. M. Gouveia, M. Carmo Barreto, Ana M. L. Seca, Ana I. Neto, Artur M. S. Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Antioxidant
Phaeophyceae Stereochemistry medicine.medical_treatment Cytotoxicity Meroditerpenes Plant Science Biology Cystoseira Bacterial growth 01 natural sciences Biochemistry HeLa chemistry.chemical_compound Meronorsesquiterpenes medicine Benzoic acid 010405 organic chemistry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Cell culture Cystoseira abies-marina Selectivity Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP Phytochemistry Letters |
| Popis: | Copyright © 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. Two new meronorsesquiterpenes (cystoazorones A and B) and two new meroditerpenes (cystoazorols A and B), along with benzoic acid were isolated from the brown macroalga Cystoseira abies-marina. The structures of the new compounds were established by 1D and 2D NMR as well as HRMS spectral analysis. The in vitro cytotoxicity and antioxidant activity of the isolated compounds were also evaluated. Cystoazorones A and B, and cystoazorol A exhibited in vitro growth inhibitory activity against HeLa cells. The HeLa cell line in log phase was found to be more sensitive to cystoazorol A than when it was in lag phase. Cystoazorol A also showed a selectivity index higher than taxol, which was used as a positive control. Cystoazorols A and B were found to be the strongest antioxidants among the compounds tested. |
| Databáze: | OpenAIRE |
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