Antimicrobial resistance profiling of coagulase-negative staphylococci in a referral center in south Italy: A surveillance study
| Autor: | Concettina Di Naso, Mario Salmeri, Daria Nicolosi, Diana Cinà, Carlo Genovese, Floriana D’Angeli |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nosocomial pathogens Surveillance study General Immunology and Microbiology Epidemiological data Virulence factors business.industry 030106 microbiology Resistance Coagulase-negative staphylococci Antimicrobial Microbiology 03 medical and health sciences 030104 developmental biology Antibiotic resistance Referral center Medicine Coagulase business |
| Popis: | Background: CoNS are part of the normal flora of the skin, upper respiratory tract and human intestine. CoNS are able to colonize host tissues or inert materials such as prosthetics, heart valves, pacemakers, and urinary and venous catheters. They can also internalize in host cells, thus eluding immune defenses and attack by antibiotics. Objective: In this study, we collected the epidemiological data and determined the antibiotic susceptibility of 828 CoNS, collected in Garibaldi Hospital (Catania, Italy) between January 2016 and October 2018. Methods: Strains were evaluated by determining the Minimum Inhibitory Concentration (MIC) using the broth microdilution method, according to the guidelines of the Clinical and Laboratory Standards Institute. The antibiotic sensitivity pattern of CoNS against eighteen antibiotics was determined. Results: For all the 828 clinical isolates, varying resistance rates were observed: ampicillin (87%), penicillin (86%), amoxicillin-clavulanate (71%), oxacillin (70%), erythromycin (69%), azithromycin (68%), levofloxacin (55%), ciprofloxacin (54%), gentamycin (47%), moxifloxacin (42%), trimethoprim-sulfamethoxazole (30%), clindamycin (28%), tetracycline (24%), rifampicin (20%), quinupristin-dalfopristin (synercid) (4%). No strains investigated demonstrated resistance to teicoplanin, vancomycin and linezolid. Conclusion: Our results highlight the importance of monitoring the evolution of CoNS resistance in order to implement control measures and reduce the risk of spread in the population. |
| Databáze: | OpenAIRE |
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