Effects of L-carnitine on tissue levels of acyl carnitine, acyl coenzyme A and high energy phosphate in ischemic dog hearts
| Autor: | Yoshikazu Suzuki, Yoshinori Masumura, Tadashi Kamikawa, Noboru Yamazaki, Akira Kobayashi |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
High-energy phosphate
medicine.medical_specialty Physiology Ischemic dog heart Coenzyme A Long chain acy1 CoA Coronary Disease Fatty Acids Nonesterified Carnitine acyl chemistry.chemical_compound Dogs Carnitine Internal medicine Mole L-carnitine medicine Animals Long chain acy1 carmitine Chemistry Myocardium Long chain acy1 carnitine Endocrinology Biochemistry Acyl Coenzyme A Energy Metabolism Cardiology and Cardiovascular Medicine Ligation Adenosine triphosphate Long-Chain Acyl CoA medicine.drug |
| Zdroj: | Japanese Circulation Journal. 45:687-694 |
| ISSN: | 1347-4839 0047-1828 |
| DOI: | 10.1253/jcj.45.687 |
| Popis: | In order to evaluate the protective effects of L-carnitine on ischemic myocardium, its effects on tissue levels of acyl carnitine, acyl coenzyme A (CoA) and high energy phosphate were studied in ischemic dog hearts. Myocardial ischemia was induced by the ligation of left anterior descending coronary artery for 15 minutes. L-carnitine ( 100 mg/kg) was administered intravenously prior to coronary ligation. In ischemic myocardium, tissue levels of free carnitine decreased from 1043 ± 358 to 623 ± 180 n mol/g (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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