Consequences at adulthood of transient inactivation of the parahippocampal and prefrontal regions during early development: new insights from a disconnection animal model for schizophrenia
| Autor: | Alain Louilot, Francisca Meyer |
|---|---|
| Přispěvatelé: | Faculty of Medicine-ULP |
| Rok vydání: | 2014 |
| Předmět: |
Dopamine
[SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Cognitive Neuroscience Hippocampus Review Article ventral subiculum lcsh:RC321-571 Behavioral Neuroscience Latent inhibition Neurochemical mental disorders medicine animal modeling latent inhibition dorsal striatum Prefrontal cortex lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ComputingMilieux_MISCELLANEOUS neonatal functional inactivation prefrontal cortex [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior entorhinal cortex Dopaminergic Subiculum medicine.disease Entorhinal cortex schizophrenia Neuropsychology and Physiological Psychology Schizophrenia [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Psychology Neuroscience |
| Zdroj: | Frontiers in Behavioral Neuroscience Frontiers in Behavioral Neuroscience, Frontiers, 2014, 8, ⟨10.3389/fnbeh.2014.00118⟩ Frontiers in Behavioral Neuroscience, Vol 8 (2014) |
| ISSN: | 1662-5153 |
| DOI: | 10.3389/fnbeh.2014.00118 |
| Popis: | The psychic disintegration characteristic of schizophrenia is thought to result from a defective connectivity, of neurodevelopmental origin, between several integrative brain regions. The parahippocampal region and the prefrontal cortex are described as the main regions affected in schizophrenia. Interestingly, latent inhibition has been found to be reduced in patients with schizophrenia, and the existence of a dopaminergic dysfunction is also generally well accepted in this disorder. In the present review, we have integrated behavioural and neurochemical data obtained in a latent inhibition protocol involving adult rats subjected to neonatal functional inactivation of the entorhinal cortex, the ventral subiculum of the hippocampus or the prefrontal cortex. The data discussed suggest a subtle and transient functional blockade during early development of the aforementioned brain regions is sufficient to induce schizophrenia-related behavioural and dopaminergic abnormalities in adulthood. In summary, these results support the view that our conceptual and methodological approach, based on functional disconnections, is valid for modeling some aspects of the pathophysiology of schizophrenia from a neurodevelopmental perspective |
| Databáze: | OpenAIRE |
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