Phagocyte-bacteria interactions
| Autor: | K. Kabha, Yona Keisari, J. Schlepper-Schafer, Liat Nissimov, Itzhak Ofek |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
0301 basic medicine
Pulmonary Surfactant-Associated Proteins Phagocyte Phagocytosis Proteolipids Receptors Cell Surface Biology Opportunistic Infections Microbiology 03 medical and health sciences 0302 clinical medicine Candida albicans Macrophages Alveolar medicine Pneumonia Bacterial Macrophage Animals Humans Lectins C-Type Pulmonary Surfactant-Associated Protein A Innate immune system Virulence Macrophages Pulmonary Surfactants 030206 dentistry General Medicine Surfactant protein A Klebsiella Infections Antibody opsonization Klebsiella pneumoniae 030104 developmental biology medicine.anatomical_structure Mannose-Binding Lectins biology.protein Protein A Mannose Receptor |
| Zdroj: | Advances in dental research. 11(1) |
| ISSN: | 0895-9374 |
| Popis: | Recognition and phagocytosis of microorganisms in a serum-poor environment represent innate immunity against many extracellular pathogens. As a paradigm for such processes, we discuss the recognition of Klebsiella pneumoniae by alveolar macrophages and monocyte-derived macrophages in the absence of serum. Macrophages recognize and subsequently kill Klebsiella expressing Man-a2/3-Man or Rha-a2/3-Rha sequences in their capsular polysaccharides by two mechanisms: (a) recognition of the capsular structures by macrophage mannose receptors, and (b) opsonization by the lung surfactant protein A (SP-A), which binds to the capsular polysaccharides of Klebsiella and to SP-A receptors on the macrophages. Sp-A may also enhance phagocytosis by increasing the activity of macrophage mannose receptors. We conclude that a specific microbial surface structure may be a target for recognition by macrophages via several mechanisms, as exemplified in the case of Klebsiella capsular polysaccharides. Multiple recognition mechanisms of pathogens by macrophages may be essential to provide innate immunity to reduce the frequency of infections caused by a relatively less virulent bacterium in the immunocompromised host. |
| Databáze: | OpenAIRE |
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