Battery of Tests for Profiling Abnormalities of Vitamin K-Dependent Coagulation Factors in Drug-Toxicity Studies in Rats
| Autor: | Yukiko Sasayama, Takeshi Iidaka, Naoko Yamasaki, Masaaki Kurata, Yoshimasa Hamada |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Vitamin Vitamin K Coagulation time Pharmacology Vitamin k General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Toxicity Tests medicine Animals Protein Precursors Drug toxicity Routine screening General Veterinary business.industry Warfarin Rats Inbred Strains General Medicine Blood Coagulation Disorders Blood Coagulation Factors Rats chemistry Factor II Activity Immunology Prothrombin Animal Science and Zoology Blood Coagulation Tests business Biomarkers medicine.drug |
| Zdroj: | Experimental Animals. 54:189-192 |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.54.189 |
| Popis: | A battery of simple tests for profiling abnormalities of vitamin K-dependent coagulation factors encountered in drug-toxicity studies was verified in rats treated with warfarin (3 and 10 mg/kg, p.o). The thrombotest, or hepaplastin-test, is useful as a follow-up test after routine screening tests for coagulation abnormalities based on PT and APTT, to rule out other coagulation-factor abnormalities. Measurement of coagulation factor activities (factors II, VII, IX and X) using factor-deficient human plasmas provides direct evidence of decreased activities of vitamin K-dependent factors. Furthermore, Echis carinatus venom coagulation time, together with factor II activity, allows us to confirm the generation of PIVKA-II. |
| Databáze: | OpenAIRE |
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