Wild mushrooms showed analgesic and cytotoxic properties along with phytoconstituent's binding affinity to COX-1, COX-2 and cytochrome P450 2C9
| Autor: | Sumaiya Akbar, Mohammad Shahadat Hossain, S. M. Moazzem Hossen, Nazim Uddin Emon, Umme Tahmida, Jannatul Mawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Daedaleopsis confragosa
H1-99 Mushroom Multidisciplinary Science (General) Traditional medicine biology Cytotoxic Chemistry In silico Brine shrimp biology.organism_classification Fomitopsis cajanderi Social sciences (General) Q1-390 Daldinia concentrica Receptors Molecular docking Bioassay Analgesic Cytotoxicity Wild mushrooms Research Article ADME |
| Zdroj: | Heliyon, Vol 7, Iss 9, Pp e07997-(2021) Heliyon |
| ISSN: | 2405-8440 |
| Popis: | This study was designed to evaluate the cytotoxic and analgesic potential of methanol extracts of five wild mushrooms available in the University of Chittagong, Bangladesh. The acetic acid-induced writhing method was used for the analgesic activity, while cytotoxicity was tested using brine shrimp lethality bioassay. In silico molecular docking and ADME/T study have been employed by using Schrodinger v11.1, BIOVIA Discovery Studio 2020 and online tool (AdmeSAR) respectively. The methanol extracts of Daldinia concentrica, Trametes lactinea, Fomitopsis cajanderi and Daedaleopsis confragosa exhibited a significant (p < 0.001) decrease in the number of writhing when compared to the control group. Except for Lentinus squarrosulus at 200 mg/kg body weight, the remaining mushroom extracts showed equal to or above 50 % inhibition of writhing. Daldinia concentrica showed the lowest LC50 values with 0.63 μg/mL, while Daedaleopsis confragosa showed the highest LC50 values of 2.33 μg/mL, indicating decisive cytotoxic action all mushrooms extracts. Considering the secondary metabolites, daldinan A and fomlactone A were found the most promising myco-compounds in analgesic and cytotoxic molecular docking studies. Besides, all the selected metabolites meet the rule of Lipinski's drug-likeliness. These results concluded that each mushroom extracts except Lentinus squarrosulus possess a potential analgesic. All the mushroom extracts embrace a promising cytotoxic activity that may guide the progress of a new drug. Wild mushrooms; Analgesic; Cytotoxic; Receptors; In silico; Molecular docking. |
| Databáze: | OpenAIRE |
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