Early life vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone
| Autor: | Robert Owen, Timothy M. Skerry, Stephanie Borg, Yongtau Lu, Gwendolen C. Reilly, Darryl W. Eyles, Harriet Buckley, Damien Lacroix, Ana Campos Marin, Nick Bishop |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Critical Care and Emergency Medicine Bone density Osteoporosis Organic chemistry Stiffness Mice 0302 clinical medicine Bone Density Pregnancy Biomechanics Vitamin D Musculoskeletal System Trauma Medicine Multidisciplinary Bone and Joint Mechanics Vitamins Skeleton (computer programming) Physical sciences Chemistry Nutritional deficiencies Bone Fracture Micronutrient Deficiencies Medicine Female Anatomy Traumatic Injury Research Article medicine.medical_specialty Mature Bone Offspring Science Finite Element Analysis Materials Science Material Properties 030209 endocrinology & metabolism Biology vitamin D deficiency Bone and Bones 03 medical and health sciences Chemical compounds Internal medicine Organic compounds medicine Vitamin D and neurology Animals Humans Mechanical Properties Skeleton Nutrition Medicine and health sciences Bone Development Vitamin D deficiency Tibia Biology and Life Sciences Bone fracture X-Ray Microtomography medicine.disease Diet Mice Inbred C57BL 030104 developmental biology Endocrinology Stress Mechanical |
| Zdroj: | PLoS One PLoS ONE, Vol 13, Iss 1, p e0190675 (2018) PLoS ONE |
| Popis: | There is increasing evidence of persistent effects of early life vitamin D exposure on later skeletal health; linking low levels in early life to smaller bone size in childhood as well as increased fracture risk later in adulthood, independently of later vitamin D status. A major determinant of bone mass acquisition across all ages is mechanical loading. We tested the hypothesis in an animal model system that early life vitamin D depletion results in abrogation of the response to mechanical loading, with consequent reduction in bone size, mass and strength during both childhood and adulthood. A murine model was created in which pregnant dams were either vitamin D deficient or replete, and their offspring moved to a vitamin D replete diet at weaning. Tibias of the offspring were mechanically loaded and bone structure, extrinsic strength and growth measured both during growth and after skeletal maturity. Offspring of vitamin D deplete mice demonstrated lower bone mass in the non loaded limb and reduced bone mass accrual in response to loading in both the growing skeleton and after skeletal maturity. Early life vitamin D depletion led to reduced bone strength and altered bone biomechanical properties. These findings suggest early life vitamin D status may, in part, determine the propensity to osteoporosis and fracture that blights later life in many individuals. |
| Databáze: | OpenAIRE |
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