Serum ionised calcium and its relationship to parathyroid hormone after tibial fracture
| Autor: | J. R. W. Hardy, PJ Gregg, S. Hay, D. Conlan |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Serum albumin Parathyroid hormone chemistry.chemical_element Bone healing Calcium Phosphates chemistry.chemical_compound Internal medicine medicine Humans Orthopedics and Sports Medicine Tibial fracture Tibia skin and connective tissue diseases Serum Albumin Aged Fracture Healing Ions biology business.industry Ionised calcium Hydrogen-Ion Concentration Middle Aged Phosphate Tibial Fractures Endocrinology chemistry Parathyroid Hormone biology.protein Female Surgery sense organs business hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Bone and Joint Surgery. British volume. :645-649 |
| ISSN: | 2044-5377 0301-620X |
| Popis: | The changes in serum adjusted ionised calcium and parathyroid hormone (PTH) were prospectively studied in 32 patients with isolated tibial fractures, treated conservatively. We measured serum albumin, adjusted total calcium, phosphate, pH, adjusted ionised calcium and PTH at intervals until the fractures had healed. The mean ionised calcium adjusted for pH fell within 24 hours of injury, and then rose to a peak at between four and six weeks. These changes cannot be explained by changes in serum pH or PTH. The restoration of normal ionised calcium levels after fracture coincided with the period when the callus was being calcified. Analysis of the changes in ionised calcium, phosphate and PTH suggests that PTH levels alter in response to changes in ionised calcium levels. PTH is highest immediately after fracture and lowest, often not recordable, at six weeks. The cause of the changes in the ionised calcium level has yet to be elucidated. |
| Databáze: | OpenAIRE |
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