Adiponectin Multimers and ADIPOQ T45G in Coronary Artery Disease in Caribbean Type 2 Diabetic Subjects of African Descent
| Autor: | Jacqueline Bangou-Bredent, Roger Chout, Roberte Aubert, Lydia Foucan, Nabila Ezourhi, Jocelyn Inamo, Michel Marre, S. Maimaitiming, J.-P. Donnet, A. Atallah, Frédéric Fumeron, Segho Hedreville |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Genotype West Indies Endocrinology Diabetes and Metabolism Black People Medicine (miscellaneous) Coronary Artery Disease Type 2 diabetes ADIPOQ Gene chemistry.chemical_compound Endocrinology High-density lipoprotein Internal medicine Diabetes mellitus medicine Humans Triglycerides Aged Polymorphism Genetic Nutrition and Dietetics Adiponectin business.industry Cholesterol HDL Odds ratio Middle Aged medicine.disease Molecular Weight Minor allele frequency Logistic Models Diabetes Mellitus Type 2 chemistry Female Metabolic syndrome business |
| Zdroj: | Obesity. 18:1466-1468 |
| ISSN: | 1930-7381 |
| DOI: | 10.1038/oby.2009.441 |
| Popis: | Ethnic differences may affect the association of adiponectin (Ad) multimers with coronary artery disease (CAD). We analyzed the associations of total Ad, Ad multimers, and T45G polymorphism of ADIPOQ gene with pre-existing CAD. We carried out a cross-sectional study of 216 Afro-Caribbean type 2 diabetic (T2D) subjects. Levels of total Ad, high molecular weight (HMW), middle molecular weight (MMW), and low molecular weight (LMW) isoforms were measured. Subjects were genotyped. Of the subjects studied, 57 had pre-existing CAD, 77% of whom have had myocardial infarction. Subjects with CAD had lower Ad levels (total and multimers) and a higher frequency carried the minor allele 45G, GG/TG, (18% vs. 8%, P = 0.03) than subjects without CAD. In logistic regression analysis, the models used evaluate Ad in the context of adjustment for metabolic syndrome characteristics. The adjusted odds ratio (OR) of CAD was increased significantly (by factors of 1.05-3.27) for males, older subjects, low high-density lipoprotein cholesterol (HDL-C), high triglycerides (TGs), and carriers of the 45 G allele. For Ad, in model 1 (including only total Ad) the adjusted OR was 2.30; P = 0.03 and, in model 2 (including the three multimers, but not total Ad), the adjusted ORs were 0.73; P = 0.52 (HMW), 2.90; P = 0.01 (MMW), and 2.08; P = 0.09 (LMW). The T45G polymorphism in the ADIPOQ gene and hypoadiponectinemia were associated with CAD in our T2D subjects of predominantly African background. This effect of Ad level was mainly related to the MMW Ad form. |
| Databáze: | OpenAIRE |
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