Reversing antibiotic resistance
| Autor: | Rebecca Hodgkinson, Derek Sharples |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Treatment outcome
Breast Neoplasms Drug resistance Pharmacology Neoplasm genetics Antibiotic resistance Acquired resistance Medicine Humans Pharmacology (medical) ATP Binding Cassette Transporter Subfamily B Member 1 P-glycoprotein Clinical Trials as Topic biology business.industry General Medicine Drug Resistance Multiple Anti-Bacterial Agents Tamoxifen Treatment Outcome Cardiovascular Diseases Drug Resistance Neoplasm biology.protein Reversing Efflux Genes MDR business |
| Zdroj: | Expert opinion on investigational drugs. 11(8) |
| ISSN: | 1354-3784 |
| Popis: | Over the past decade many well-tried chemotherapeutic agents have lost their effectiveness. This is due to a phenomenon referred to as multi-drug resistance. The most likely cause of multi-drug resistance is an increase in the activity of an efflux pump mediated through the actions of a P-glycoprotein. There is a continuing search, not only for new chemotherapeutic agents, but also for agents that can reverse the acquired resistance to existing agents. |
| Databáze: | OpenAIRE |
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