Photopic light-mediated down-regulation of local α1A-adrenergic signaling protects blood-retina barrier in experimental autoimmune uveoretinitis
Autor: | Masaaki Murakami, Daisuke Kamimura, Andrea Stofkova, Takuto Ohki, Mitsutoshi Ota, Yasunobu Arima |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Central Nervous System Superior cervical ganglion Adrenergic receptor Epinephrine Light T-Lymphocytes Central nervous system lcsh:Medicine Inflammation Autoimmunity Superior Cervical Ganglion Article Autoimmune Diseases 03 medical and health sciences Norepinephrine Mice 0302 clinical medicine Immune system Adrenergic Agents Receptors Adrenergic alpha-1 Blood-Retinal Barrier medicine Animals lcsh:Science Neurons Mice Inbred BALB C Multidisciplinary Color Vision business.industry lcsh:R Retinitis Endothelial Cells Receptors Adrenergic Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Blood-Brain Barrier Reflex Female lcsh:Q medicine.symptom business Neuroscience 030217 neurology & neurosurgery medicine.drug Photopic vision |
Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | We have reported the gateway reflex, which describes specific neural activations that regulate immune cell gateways at specific blood vessels in the central nervous system (CNS). Four types of gateway reflexes exist, all of which induce alterations in endothelial cells at specific vessels of the blood-brain barrier followed by inflammation in the CNS in the presence of CNS-autoreactive T cells. Here we report a new gateway reflex that suppresses the development of retinal inflammation by using an autoreactive T cell-mediated ocular inflammation model. Exposure to photopic light down-regulated the adrenoceptor pathway to attenuate ocular inflammation by suppressing breaching of the blood-retina barrier. Mechanistic analysis showed that exposure to photopic light down-regulates the expression of α1A-adrenoceptor (α1AAR) due to high levels of norepinephrine and epinephrine, subsequently suppressing inflammation. Surgical ablation of the superior cervical ganglion (SCG) did not negate the protective effect of photopic light, suggesting the involvement of retinal noradrenergic neurons rather than sympathetic neurons from the SCG. Blockade of α1AAR signaling under mesopic light recapitulated the protective effect of photopic light. Thus, targeting regional adrenoceptor signaling might represent a novel therapeutic strategy for autoimmune diseases including those that affect organs separated by barriers such as the CNS and eyes. |
Databáze: | OpenAIRE |
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