Clinicopathological characteristics and treatment outcomes of occult breast cancer: a SEER population-based study
| Autor: | Zong-Chao Gou, Xi-Yu Liu, Gen-Hong Di, Yi Xiao, Shen Zhao, Li-Ping Ge, Yi-Zhou Jiang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Population Sentinel lymph node treatment outcomes 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine 030212 general & internal medicine education Original Research education.field_of_study business.industry Axillary Lymph Node Dissection clinicopathological characteristics Retrospective cohort study occult breast cancer medicine.disease SEER database Radiation therapy Cancer Management and Research 030220 oncology & carcinogenesis Propensity score matching business Mastectomy |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s169019 |
| Popis: | Li-Ping Ge,1,2,* Xi-Yu Liu,1,2,* Yi Xiao,1,2 Zong-Chao Gou,1,2 Shen Zhao,1,2 Yi-Zhou Jiang,1,2 Gen-Hong Di1,2 1Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China *These authors contributed equally to this work Background: Occult breast cancer (OBC) is a rare type of breast cancer that has not been well studied. The clinicopathological characteristics and treatment recommendations for OBC are based on a limited number of retrospective studies and thus remain controversial.Patients and methods: We identified 479 OBC patients and 115,739 non-OBC patients from 2004 to 2014 in and the Surveillance, Epidemiology, and End Results (SEER) database. The clinicopathological characteristics and survival outcomes were compared between OBC and non-OBC patients. We used the propensity score 1:1 matching analysis to evaluate OBC vs non-OBC comparison using balanced groups with respect to the observed covariates. We further divided the OBC population into four groups based on different treatment strategies. Univariable and multivariable analyses were used to calculate and compare the four treatment outcomes within the OBC population.Results: OBC patients were older, exhibited a more advanced stage, a higher rate of negative estrogen receptor and progesterone receptor status, a higher rate of HER2-positive status, and a higher rate of ≥10 positive lymph nodes, and were less likely to undergo surgical treatment than non-OBC patients. After adjustments for clinicopathological factors, the OBC patients exhibited a significantly better survival than the non-OBC patients (P |
| Databáze: | OpenAIRE |
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