Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study
| Autor: | Kirsten R. Müller-Vahl, Carolin Fremer, Jelena Ivkovic, Chan Beals, Henrik Loft, Christoph Schindler |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Movement disorders Pyrrolidines Tics Placebo Tourette syndrome Severity of Illness Index Piperazines law.invention 03 medical and health sciences 0302 clinical medicine Quality of life Randomized controlled trial law Internal medicine mental disorders Medicine Humans business.industry medicine.disease Monoacylglycerol Lipases Monoacylglycerol lipase Clinical trial 030104 developmental biology Neurology Quality of Life Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Tourette Syndrome |
| Zdroj: | Movement disorders : official journal of the Movement Disorder SocietyReferences. 36(10) |
| ISSN: | 1531-8257 |
| Popis: | Background Modulation of the endocannabinoid system via monoacylglycerol lipase inhibition with Lu AG06466 (formerly known as ABX-1431) has previously been shown to reduce tics in patients with Tourette syndrome. Objective The aim of this study was to evaluate the efficacy and safety of Lu AG06466 in reducing tics, premonitory urges, and comorbidities in patients with Tourette syndrome. Methods This was a 12-week, multicenter, randomized, placebo-controlled, double-blind clinical trial of Lu AG06466 given at two dose levels in 49 adults with Tourette syndrome. Results Both treatment groups showed improvement on the Total Tic Score of the Yale Global Tic Severity Scale; the mean (95% CI) treatment difference at week 8 of 3.0 (0.1, 5.9) (P = 0.043) favored placebo. No significant differences were seen for other endpoints assessing changes in tic severity, premonitory urges, quality of life, and common psychiatric comorbidities. Treatment with Lu-AG06466 was generally safe. Conclusions There was no evidence that Lu AG06466 has efficacy in suppressing tics. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| Databáze: | OpenAIRE |
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