3-Aminobenzamide inhibition of protein kinase C at a cellular level

Autor:	Roberta Ricciarelli, Angelo Azzi, Letizia Palomba, Orazio Cantoni
Rok vydání:	1998
Předmět:	Biophysics Apoptosis Mitogen-activated protein kinase kinase Biochemistry Cell Line MAP2K7 Structural Biology Genetics Humans c-Raf Enzyme Inhibitors Protein kinase A Molecular Biology Protein Kinase C Dose-Response Relationship Drug biology MAP kinase kinase kinase Chemistry Cyclin-dependent kinase 2 Poly-(ADP-ribose)-polymerase Hydrogen Peroxide Cell Biology Protein kinase R Molecular biology Recombinant Proteins 3-Aminobenzamide Enzyme Induction Protein kinase C inhibition Benzamides biology.protein Tetradecanoylphorbol Acetate Cyclin-dependent kinase 9
Zdroj:	FEBS Letters. 431:465-467
ISSN:	0014-5793
DOI:	10.1016/s0014-5793(98)00811-4
Popis:	3-Aminobenzamide, a known inhibitor of poly-(ADP-ribose)-polymerase has been found in the cell line U-937 to inhibit protein kinase C at the same concentration as poly-(ADP-ribose)-polymerase. 3-Aminobenzamide was not able, however, to inhibit the isolated enzyme. An indirect mechanism of protein kinase C inhibition is proposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b5cd1e334fec042b94e021cc9287e7 https://doi.org/10.1016/s0014-5793(98)00811-4 Zobrazit plný text záznamu Plný text