Impact of Suppression of Viral Replication by Highly Active Antiretroviral Therapy on Immune Function and Phenotype in Chronic HIV-1 Infection
| Autor: | Hernan Valdez, Michael M. Lederman, Kathy Medvik, Christoph Lange, Juan Sierra Madero, Christina Pacheko, Claudia Carranza, Robert Asaad |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Anti-HIV Agents T-Lymphocytes Lymphocyte HIV Infections Human leukocyte antigen Lymphocyte proliferation CD8-Positive T-Lymphocytes Biology CD38 Lymphocyte Activation NAD+ Nucleosidase Immune system CD28 Antigens Antigen Antigens CD Antiretroviral Therapy Highly Active Immunopathology medicine Humans Hypersensitivity Delayed Pharmacology (medical) Lymphocyte Count ADP-ribosyl Cyclase Membrane Glycoproteins HLA-DR Antigens ADP-ribosyl Cyclase 1 Antigens Differentiation Virology CD4 Lymphocyte Count Cross-Sectional Studies Infectious Diseases medicine.anatomical_structure Delayed hypersensitivity Chronic Disease Immunology HIV-1 |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 30:33-40 |
| ISSN: | 1525-4135 |
| Popis: | We compared immune phenotypes, lymphocyte proliferation (LP), and delayed type hypersensitivity (DTH) responses in 28 male antiretroviral treatment-naive and experienced HIV-1-infected patients, matched pair-wise according to age and CD4 + T-lymphocyte count. Median CD4 + T-lymphocyte counts were 441 cells/μL and 483 cells/μL and median CD4 + T-lymphocyte nadirs were 435 cells/μL and 150 cells/μL in both groups, respectively. Absolute numbers of circulating T-lymphocyte subpopulations and proportions of naive and memory T-lymphocytes were comparable in the two groups. Untreated patients had greater proportions of activated CD4 + (p |
| Databáze: | OpenAIRE |
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