Intra-cerebral ventricular infusion of 5-IODO-2-deoxyuridine (IUDR) as a radiosensitizer in the treatment of a rat glioma
| Autor: | Sallie S. Boggs, E.S. Redgate, Melvin Deutsch, Edwin R. Fisher, Arleta B. Rewers |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Radiation-Sensitizing Agents Cancer Research Radiosensitizer medicine.medical_treatment Central nervous system Brain tumor chemistry.chemical_compound Cerebrospinal fluid Idoxuridine Glioma medicine Animals Radiology Nuclear Medicine and imaging Injections Intraventricular Radiation Brain Neoplasms business.industry medicine.disease Rats Inbred F344 Deoxyuridine Rats Death Radiation therapy medicine.anatomical_structure Oncology chemistry Cerebral ventricle business Nuclear medicine Neoplasm Transplantation |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 19:85-87 |
| ISSN: | 0360-3016 |
| Popis: | The efficacy of 5-iodo-2-deoxyuridine (IUDR) as a radiosensitizer when administered by continuous infusion into the cerebral spinal fluid (CSF) of the lateral cerebral ventricle was evaluated in a 9L gliosarcoma rat brain tumor model. Stereotactic implantation of a 5 x 10(4) tumor cell suspension into the left caudate nucleus was carried out in four groups of 10 rats each. Control animals had a median survival of 16.9 days (range 16-21 days). IUDR, 8.4 mg over 7 days administered by continuous infusion into the left lateral ventricle produced a slight survival advantage (median survival 21.5 days, range 12-56). Irradiation of the entire brain, 8 Gy on days 4, 6 and 7 after tumor cell implantation also produced a slight improvement in survival (median 19.5 days, range 17-34). The combination of radiation and IUDR infusion into the CSF produced a marked survival advantage (median 30.5, range 22-54) compared to the control and single modality treatment groups. This is the first demonstration of the effectiveness of IUDR as a radiosensitizer when administered into the lateral cerebral ventricle in the treatment of an intraparenchymal brain tumor. |
| Databáze: | OpenAIRE |
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