Expression of Integrins, Anchorage Dependent Apoptosis and Invasiveness of Multidrug Resistant Human Breast Carcinoma Cells

Autor:	Berman, A. E., Chubukina, A. N., Kozlova, N. I., Morozevich, G. E., Shtil, A. A.
Jazyk:	angličtina
Rok vydání:	2004
Předmět:	anoikis multidrug resistance integrins tumor invasion skin and connective tissue diseases
Popis:	The aim of the study was to investigate the role of integrins in anchorage dependent apoptosis (anoikis) and in vitro invasion of human breast cancer cell line MCF-7 and its multidrug resistant subline MCF-7Dox. Acquisition of MDR was associated with markedly decreased expression of collagen specific a2ß1 and avß3 integrins, laminin specific a3ß1 and a6ß1 receptors and dramatic up-regulation of fibronectin specific a5ß1 integrin. The MDR subline was substantially more resistant to anoikis than their wild type counterparts. Furthermore, MCF-7Dox cells secreted MMP-9 collagenase and invaded Matrigel. We demonstrate for the first time that stimulation of ß1 integrin signaling strongly sensitizes MCF-7 cells to anoikis. EXCLI Journal ; Vol. 3, 2004
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b3869b52adfc8c8dbb38a9f33018f2 http://hdl.handle.net/2003/25638 Zobrazit plný text záznamu